Remedy: Re-balance from Within

Before the invention of modern medicine, not too distant from the present day, the cures and treatments for the ailments of the community were known (and protected) by the women and men of the community. They had experience and vast knowledge handed down from those before them regarding the forests, fields, mountains and streams, that provided medicinal plants, herbs, and fungi (until modern nomenclature many fungi were described and seen as plants), which could be used for: aches and bruises, to improve fertility, to enhance immune function and combat disease, and some that were used during labor and pregnancy*. There are still many rural communities that rely on the use of and knowledge of these biological allies, which have provided modern medicines with a litany of compounds that have since been synthesized and standardized (such as antibiotics and statins for lowering cholesterol), to provide them the same benefits that have been known throughout the ages and are being (re)discovered to be scientifically and medically beneficial* (modern clinical studies have been and are being performed to investigate efficacy of many fungi and plants).

Our flagship tincture, Remedy, is a combination 5 mushroom extract, each with investigated benefits and with a lengthy record of known usage: some for centuries…some millennia. Included in our product are: Reishi¹ (Ganoderma spp.), Shiitake² (Lentinula edodes), Turkey Tail³ (Trametes versicolor), Lion’s Mane⁴ (Hericium erinaceus), and Chaga⁵ (Inonotus obliquus). All of these have been shown to possess different capabilities, such as:

• cancer fighting
• tumor suppressing
• cholesterol lowering
• antifungal
• anti-parasitic
• antioxidant
• antibacterial
• anti-diabetic
• neuroregenerative
• anxiolytic
• and mitigating depression, along with many benefits that are being discovered*.

We encourage the well-informed use of these fungi - so go on the journey of revelation about the potency of these fungal allies.

Our modern system has become unbalanced as is increasingly evident by the disequilibrium that we observe considering our relationship with the natural realm.

We recommend using Remedy daily to support immune system function, to combat fatigue and mental fog, to aid the digestive system, and to promote overall health and well-being. We invite you to join us in reconnecting with the body’s innate intelligence and homeostatic balance. Find your center, discover your balance: Your Health is True Wealth.

For my nerdy folks and other interested parties, read more below:

1. “Diverse groups of chemical compounds with pharmacological activities, isolated from the mycelia and fruiting bodies of G. lucidum are triterpenoids, polysaccharides (β-D-glucans), proteins, amino acids, nucleosides, alkaloids, steroids, lactones, lectins, fatty acids, and enzymes. The biologically active compounds as primarily triterpenoids and polysaccharides of G. lucidum have been reported to possess hepatoprotective, antihypertensive, hypocholesterolemic, antihistaminic effects and antioxidant, antitumor, immunomodulatory, and antiangiogenic activities. Several formulations have been developed, patented and used as nutraceuticals, nutriceuticals and pharmaceuticals from G. lucidum’s water or ethanol extracts and rarely purified active compounds. As the result of clinical trials, various products have commercially become available as syrup, injection, tablet, tincture or bolus of powdered medicine and an ingredient or additive in dark chocolate bars and organic fermented medicinal mushroom drink mixes such as green teas, coffees, and hot cacaos.” (Health Benefits of Ganoderma lucidum as a Medicinal Mushroom. Bulam S et. al., Turkish Journal of Agriculture - Food Science and Technology, 7(sp1): 84-93, 2019, DOI: https://doi.org/10.24925/turjaf.v7isp1.84-93.2728).
2. “It has a low lipid content, high fiber content, and a considerable amount of proteins; it also contains B vitamins and minerals in addition to a wide range of functional metabolites including polysaccharides, polysaccharopeptides, lectins, and secondary metabolites with bioactivity, e.g., lentinan, a β-(1-3)-glucan with immunomodulatory activity, among others. Extracts and pure compounds of shiitake exhibit antibacterial, antifungal, cytostatic, antioxidant, anticancer, and immunomodulatory activity. Because of these attributes, different products derived from shiitake are on the market and are sold as dietary supplements.” (Review of Bioactive Molecules Production, Biomass, and Basidiomata of Shiitake Culinary-Medicinal Mushrooms, Lentinus edodes (Agaricomycetes). Gaitán-Hernández R et. al., International Journal of Medicinal Mushrooms, Volume 21, 2019 Issue 9, DOI: 10.1615/IntJMedMushrooms.2019031849 https://www.dl.begellhouse.com/journals/708ae68d64b17c52,11caa79135e177b5,042f94684dee8813.html ).
3. “While medicinal mushrooms generally confer broad immune activity, individual species often possess unique immunological properties. Trametes versicolor (Tv), commonly known as Turkey tail and previously named Coriolus versicolor, is known to enhance innate and adaptive immune responses [19, 20]. Recent clinical research involving consumption of Tv mycelium on rice substrate by Standish and colleagues [21] suggests NK cell induction in women with breast cancer. Other researchers cite antitumor effects [4, 22, 23], but this is generally considered to be a result of its underlying immunologic activity [24]. Tv contains precursors to the proteoglycans polysaccharide peptide (PSP) and polysaccharide-K (Krestin, PSK), the latter of which is frequently prescribed to gastric cancer patients in Japan [25]. The constituents responsible for these immunological effects are believed to be the polysaccharides. However, recent research suggests that the lipid fraction of PSK isolated from Tv is instrumental to its TLR-2 induction activity [26].” (The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro. Benson K, Stamets P, et.al., BMC Complementary and Alternative Medicine, 2019, DOI: https://doi.org/10.1186/s12906-019-2681-7).
4. “Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system. Hericenones and erinacines isolated from the medicinal mushroom Hericium erinaceus can induce NGF synthesis in nerve cells. In this study, we evaluated the synergistic interaction between H. erinaceus aqueous extract and exogenous NGF on the neurite outgrowth stimulation of neuroblastoma-glioma cell NG108-15. The neuroprotective effect of the mushroom extract toward oxidative stress was also studied. Aqueous extract of H. erinaceus was shown to be non-cytotoxic to human lung fibroblast MRC-5 and NG108-15 cells. The combination of 10 ng/mL NGF with 1 μg/mL mushroom extract yielded the highest percentage increase of 60.6% neurite outgrowth. The extract contained neuroactive compounds that induced the secretion of extracellular NGF in NG108-15 cells, thereby promoting neurite outgrowth activity. However, the H. erinaceus extract failed to protect NG108-15 cells subjected to oxidative stress when applied in pre-treatment and co-treatment modes. In conclusion, the aqueous extract of H. erinaceus contained neuroactive compounds which induced NGF-synthesis and promoted neurite outgrowth in NG108-15 cells. The extract also enhanced the neurite outgrowth stimulation activity of NGF when applied in combination. The aqueous preparation of H. erinaceus had neurotrophic but not neuroprotective activities.” (Neurotrophic Properties of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Lai P, Naidu M, et.al., International Journal of Medicinal Mushrooms, Volume 15, 2013 Issue 6, pages 539-554. DOI: 10.1615/IntJMedMushr.v15.i6.30).

“The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial properties, this overview surveys and consolidates the widely scattered literature on the chemistry (isolation and structural characterization) of polysaccharides and secondary metabolites such as erinacines, hericerins, hericenones, resorcinols, steroids, mono- and diterpenes, and volatile aroma compounds, nutritional composition, food and industrial uses, and exceptional nutritional and health-promoting aspects of H. erinaceus. The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression. The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties. A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases.”  (Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. Mendel Friedman, Journal of Agricultural and Food Chemistry 2015 63 (32), 7108-7123 DOI: 10.1021/acs.jafc.5b02914).

5. “The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilát (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment. Many reports have been published concerning the health promoting functions of this mushroom, including antibacterial, hepatoprotective, anti-inflammatory, antitumor, and antioxidant activities. The purpose of the present study was evaluation of in vitro anticancer activity of fraction IO4 isolated from I. obliquus. The effect on cell proliferation, motility and viability was assessed in a range of cancer and normal cells. Chaga fraction prepared from dried fruiting bodies was subjected to anticancer evaluation in human lung carcinoma (A549), colon adenocarcinoma (HT-29), and rat glioma (C6) cell cultures. Human skin fibroblasts (HSF), bovine aorta endothelial cells (BAEC), models of rat oligodendrocytes (OLN-93), hepatocytes (Fao), rat astroglia, and mouse neurons (P19) were applied to test toxicity in normal cells. The following methods were applied: tumor cell proliferation (MTT assay and BrdU assay), cytotoxicity (LDH assay), tumor cell motility (wound assay), tumor cell morphology (May-Grünwald-Giemsa staining), and death detection (ELISA). Chaga fraction elicited anticancer effects which were attributed to decreased tumor cell proliferation, motility and morphological changes induction. Of note is the fact that it produced no or low toxicity in tested normal cells. The data presented could open interesting paths for further investigations of fraction IO4 as a potential anticancer agent.” (Anticancer Effects of Fraction Isolated from Fruiting Bodies of Chaga Medicinal Mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): In Vitro Studies. Lemieszek M K, et.al., International Journal of Medicinal Mushrooms, Volume 13, 2011 Issue 2, pages 131-143. DOI: 10.1615/IntJMedMushr.v13.i2.50).

*FDA Disclaimer: This product has not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure, or prevent any disease or condition. If you have a medical condition, are taking medications, or are pregnant or nursing consult your healthcare professional before using this product. Furthermore, these statements are made with explicit reservation of all rights and to serve as informational purposes only.

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